Yes, A female ferret will die if she doesn’t find a mate. When she is in heat and if she doesn’t mate, the female will secrete high levels of oestrogen.
If this hormone stays in the blood for a prolonged period of time, it will cause a progressive depression of bone marrow which results in a severe, life threatening aplastic anaemia.
The female simply needs the act of mating – not necessarily pregnancy – which will induce ovulation and will take her out of estrus.
Ferrets are prone to heat stress, and temperatures over 29 to 32 degree Celsius. Every effort should be made to keep your ferret’s cage at a safe and comfortable temperature.
Your ferret is actually happier in frostier temperatures. Overall, ferrets are cool-weather animals, and don’t handle heat well. If your ferrets are healthy and have a full winter coat, they will be quite happy living in what we would consider chilly indoor temperatures (such as 60 F or 15 C).
Unless they are going to be used for breeding purposes, female ferrets will go into extended heat. A female that does not mate can die of a plastic anemia without medical intervention. It is possible to use a vasectomised male to take a female out of heat.
If female ferrets go into heat and do not mate or are not spayed, they can develop a severe anemia.
This is because estrogen can cause the bone marrow to stop producing red blood cells.